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While neurons are predominantly oxidative, yielding ATP through mitochondrial activity, astrocytes are mostly glycolytic, producing pyruvate and lactate (Magistretti and Allaman, 2015

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Each of these peptides exists in two chemically distinct variants the free base and the acetate salt with different solubility, stability, and potentially different safety profiles

Moreover, HDAC4 deficiency attenuated the effects of KD and promoted iron overload and lipid peroxidation, contributing to neuronal ferroptosis